CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms.

Transduction with Cas9 alone led to somewhat lower BAY and Cilo responses as compared to NT controls, which is theoretically possible due to the adenoviral treatment; however, these differences did not reach statistical significance ( Figure 3 D,H).

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