The Curcumin Analog PAC Is a Potential Solution for the Treatment of Triple-Negative Breast Cancer by Modulating the Gene Expression of DNA Repair Pathways.

We observed that in both, there was a clear trend of decreasing cell viability in those treated while an increase in proliferation was present among the controls, with significant differences between the two conditions, as illustrated in Figure 2 A,C.

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Versus the vehicle control, our study also demonstrates that the antiapoptotic gene (Bcl-2) had a highly significant decrease after being treated with PAC.

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