Defects in intratumoral arginine metabolism attenuate the replication and therapeutic efficacy of oncolytic myxoma virus.

J Immunother Cancer · 2023 · PMC10254609 · PMID 37270180

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Similarly, while MyxASS1 and MyxASS1 FS displayed similar viral titers in tumors derived from ASS1 + B16F10 cells, MyxASS1 displayed a strong trend towards increased viral titers in tumors derived from two distinct ASS1 KO B16/F10 cell lines ( figure 6D ) as well as significantly increased titers in tumors derived from intrinsically ASS1-deficient A9F1 cells ( figure 6E ).

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