Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation.

Commun Biol · 2023 · PMC10257653 · PMID 37301913

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nominally significantno p-value reported

cis -eQTLs enrichment We obtained the variant-gene pairs from the GTEx release version 8 (URL: https://gtexportal.org/home/datasets ) that collected nominally significant cis -eQTLs.

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highly significantno p-value reported

Importantly, the same analyses revealed that the evolutionary pressure in pG4 G-tracts of both 1 kb and 0.2 kb promoters were highly significant in both populations.

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