Effects of one-year supplementation with <i>Phyllanthus niruri</i> on fibrosis score and metabolic markers in patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial.

Although the difference in changes of liver enzyme levels between the intervention and control groups did not reach statistical significance, there was a declining trend with a larger magnitude in the intervention group, suggesting the potential anti -NAFLD effects of P. niruri in humans.

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However, transient elastography has been demonstrated to have acceptable accuracy in diagnosing and staging steatosis and fibrosis [ 37 ], leading to an increasing trend in the use of CAP and fibrosis scores as endpoints for studies of NAFLD treatment [ [24] , [25] , [26] , [27] , [28] ].

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