Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis.

Specifically, the inter‐hemispheric differences in the SCZ samples became highly significant after excluding one small dataset ( p < .002). 3.6.

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An initial synthesis of the volume data from the left and right habenula using a paired samples t ‐test also supported this point: no significant interhemispheric differences for either the healthy samples ( t (24) = 1.443, p = .162, Cohen d = 0.289), or the patients with SCZ ( t (4) = −0.550, p = .612, d = −0.246); there appeared to be a nominally significant difference in MDD subgroup ( t (10) = 2.403, p = .037, d = 0.725), but it did not survive correction of multiple testing.

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