The 27-gene IO score is associated with efficacy of PD-1/L1 inhibitors independent of FGFR expression in a real-world metastatic urothelial carcinoma cohort.

While the IO score and IO + /TMB high model approached significance, TMB high alone did not in this subgroup (TMB HR 0.6162, 95%CI 0.1985–1.913, p = 0.402) (Figure S2B).

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Although only trending toward significance, likely due to the low number of patients in this subgroup analysis, these data suggest that there may be a clinically meaningful benefit from the IO score or the IO + /TMB high model (IO HR 0.3001, 95%CI 0.0773–1.165, p = 0.0819; IO + /TMB high HR 0.3432, 95%CI 0.09792–1.203, p = 0.0946) (Figure S2A).

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