“approached significance”

While no individual epistatic association was genome-wide significant (p< 2.56e-10), several approached significance (p< 3e-8).

Secondary Analysis of GWAS Finding In our study, the variant rs4242007 was in near-complete linkage disequilibrium ( r 2 = 0.98) with rs4074555 (chr4:57110400, C/A), which itself approached significance in the primary GWAS ( p = 1.07 × 10 −7 ).

However, the locus at 9q31 spanning RAD23B identified in the analysis of AD+A again approached significance (Table 3 , best SNP rs60819822, O.R. 0.86 (0.81, 0.91), p = 1.75 × 10 −7 ).

It is interesting to note, however, that H3 tSNPs approached significance for protection against degeneration of the macula and the posterior pole of the retina ( p = 1.76E−4–9.49E−4, OR = 0.91; Table S19 ).

This difference approached significance using a paired t -test, p < 0.001 (Cohen’s d = 1.10).

Finally, the interaction group by delay approached significance, indicating that PWS increased their tapping variability more prominently as the delay increased (ꭓ 2 (1) = 29.09, p < 0.001), compared to the control group (ꭓ 2 (1) = 18.09, p < 0.001).

Although the relationships between sentinel spectral features and markers of inflammation were all significantly attenuated when controlling for BMI (which accounted for 13%–31% of the unadjusted associations, P = 0.03 to P = 2.0 × 10 −16 ; Table 5 ), almost all of the feature-inflammation associations remained significant ( P = 0.0002 to P = 2.0 × 10 −16 ; Table 5 ), with the exception of the association between glutamine/proline betaine at IL-6, which approached significance ( β = −0.25 ± 0.08; P = 0.002; Table 5 ).

The results produced no significant differences with the exception of the “look after her/him” act which approached significance [ t (399) = −3.14, p = .002, d = .34].

The interaction between day-level autonomy support t and autonomy orientation t on day-level meaningful work t+1 approached significance ( b = − 0.048, p = .003), so was the interaction between day-level perceived prosocial impact t and prosocial orientation on day-level meaningful t+1 work ( b = 0.075, p = .001).

The negative association between depression and being employed approached significance (ß = −0.23, p = 0.004), which correlates to earlier studies regarding connections between self-efficacy 89 and self-worth 93 and employment.

The ratio of IRS‐1 S636/IRS‐1 approached significance (one‐way ANOVA p = 0.0051, post hoc ctl‐HI p = 0.073) following HI treatment and was higher following HI/MET treatment relative to ctl ( p = 0.0039) and MET ( p = 0.0017) groups (Figure 2d ).

No relationships were evident for irritability, tension (this approached significance, p = .0058), salivation, or the two affectively positive factors (positive anticipation, positive mood). 3.4.

Although the data for the foveal area approached significance (patients: 33.41 ± 6.44 (33.85 [27.20, 38.83]%); control group: 27.71 ± 6.28 (27.14 [24.25, 30.42]%); p = 0.006), the consistent trend of reduced flow density persisted.

Due to a small variance, differences in the 3 wo group approached significance (t(4.5) = −4.10, p = 0.012, p adj = 0.059, d = −2.90 [−11.60, −1.68]).

Cosinor analyses revealed 24 h rhythmicity for NR1D2 and PER2 and approached significance for CRY1 ( p = 0.013, p = 0.013, and p = 0.051, respectively) in week 20 in the treatment group only.

Because the difference in BMI among the subgroups approached significance (Supplementary Table 3, Supplemental digital content 3, http://links.lww.com/PG/A299 P = 0.018), we added BMI as a covariate to the linear mixed model to account for this parameter in the association between methylation and tinnitus status.

For rodents, month did not influence predation ( χ 2 = 9.75, df = 5, p = .083) and bird predation only approached significance for lower predation in late July ( χ 2 = 13.32, df = 5, p = .021, Tukey's post hoc, z = −2.64, p = .088) than late September.

The interaction between head colour morph and sex approached significance ( Table 2 ) with black-headed males showing a lower frequency of head movements than juveniles (bootstrapping: p = 0.030; Fig 4 ).

After controlling for specialty, being confident still predicted a preference for a model of ‘request with support from genetics services’ over any other model for outpatients (OR 2.81, 99% CI 1.11–7.08, p = 0.004) but only approached significance for inpatients ( p = 0.031).

5 and 6 ) and approached significance for improvements in BDI-II ( F (1,104.4) = 4.81, P = 0.031) for the posterior lDLPFC site.

These analyses revealed a complex, opposite pattern of change from weeks 1 to 12 in responders ( p =.024, PCCE=55.8%), but only approached significance in non-responders after Bonferroni correction ( p = .032, PCCE=56.6%; Figure 2 ).

Negative usability comments for the 4SQT approached significance ( W =4.1; P =.04; Table 1 ), but this result was not statistically significant.

The rate of increasing CDR-SB score reached or approached significance in the model comparing the HS-A group to all other groups (LATE-NC: 1.45, 95% CI [0.13, 2.74], p = 0.046; ADNC: 2.1, 95% CI [0.61, 3.5], p = 0.012; no pathology: 0.96, 95% CI [−0.041, 1.96], p = 0.093).

Post hoc tests showed either that aerobic energy expenditure in all of the FAC groups was significantly lower than that in the group with no impairments or that this difference approached significance (FAC 3 for sweeping [ P = .047] and cycling [ P = .014]; FAC 5 for walking [ P = .022] and sweeping [ P = .029]).

Observe ( β = − 0.24, t = − 1.98, p = 0.05) mindfulness approached significance such that higher observe mindfulness was associated with lower emotional eating-positive; however, this relationship was ultimately not significant ( p ≥ 0.05).