Colchicine attenuates the electrical remodeling of post-operative atrial fibrillation through inhibited expression of immune-related hub genes and stabilization of microtubules.

Moreover, colchicine significantly alleviated the AF burden in LPS-stimulated mice under programmed intracardiac stimulation by reducing the number of episodes ( p = 0.0036, Figure 4 I) and episode durations ( p = 0.0231, Figure 4 J) , whereas administration of AG-1478 alone showed a trend to reduce the occurrence of AF, but with no statistically significant difference in episode number ( p = 0.222, Figure 4 I) or episode time ( p = 0.187, Figure 4 J) .

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