a significant trendp < 0.05
We observed a significant trend for the medians (Cuzick test for medians trend, p < 0.05) of the relative expression of miR-143-3p (p = 0.029), miR-143-5p (p = 0.020) and miR-30b-5p (p = 0.033) with increasing severity of the lesions (Fig. 3 a).