Differences in disability accumulation between people who exclusively experienced non-disabling relapses in the early MS period and those who experienced any disabling relapses in early MS did not reach statistical significance ( Figure 1(d)–(f) ): untreated ( n = 192 vs 333; HR = 0.77; 95% CI = 0.54–1.09); platform DMTs (n = 925 vs 1510; HR = 0.91, 95% CI = 0.75–1.09); high-efficacy DMTs ( n = 595 vs 1631; HR = 0.83, 95% CI = 0.65–1.04).
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Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis.
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