Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection.

Mol Ther Nucleic Acids · 2023 · PMC10280097 · PMID 37346977

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49%, respectively), microglia showed a trend of increased ASO activity with a 65% reduction in mRNA measured ( Figures 1 H–1J).

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