Dual CSF1R inhibition and CD40 activation demonstrates anti-tumor activity in a 3D macrophage- HER2⁺ breast cancer spheroid model.

HLA-DR expression, as marker of macrophage activation, showed a trend toward increased expression in response to CSF1Ri, which was further accentuated in combination with anti-CD40 mAb treatment over 4 days ( Supplementary Figure S3C ).

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