Haploinsufficiency of the essential gene <i>Rps12</i> causes defects in erythropoiesis and hematopoietic stem cell maintenance.

As expected, RT-PCR results showed a highly significant decrease in the Rps12 mRNA levels in Rps12 KO/+ cells ( Figure 3—figure supplement 2A ) but no difference in the levels of Snord100 and Snora33 ( Figure 3—figure supplement 2B ).

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Western-blot analysis also showed a strong trend toward decreased Rps12 protein levels in cKit + bone marrow cells ( Figure 3—figure supplement 2C ).

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