Global, regional, and national burden of kidney dysfunction from 1990 to 2019: a systematic analysis from the global burden of disease study 2019.

A decreasing trend was observed for ASMR and ASDR of those age 60 to 90 years old with a reverse trend only occurs in 80 to 84 years old (Figure S 5 ).

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A generally increasing trend was observed in SEV of all seven other GBD super regions, North Africa and Middle East had the fastest increasing SEV as well as the highest ASMR and ASDR from 1990 to 2019 in this seven GBD super regions while High-income posed a relatively stable SEV as well as the lowest ASMR and ASDR, which showed a trend of general decrease (Figure S 3 ).

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As for SEV of those age 60 years old or older, there exists a rapidly decline trend before 80 years old however an increasing trend in those aged 80 to 90 years old then decreased in 95+ age group.

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