Male rodent perirhinal cortex, but not ventral hippocampus, inhibition induces approach bias under object-based approach-avoidance conflict.

When faced with high conflict, PRC inhibition led to animals spending significantly more time by the sucrose dispenser compared to high conflict test sessions without optogenetic inhibition (p<0.0001), whereas an increase in time spent by the dispenser elicited by low conflict stimuli approached significance (p=0.052; laser: F(1,18)=24.34, p<0.0001, η p 2 = 0.57; laser × conflict: F(2,32)=5.43, p=0.0093, η p 2 = 0.25) ( Figure 4a–b ).

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