The synaptophysin expression did not reach statistical significance by either lipopolysaccharide or propofol treatments at the time point in our experiment ( Figures 1E, H ). 3.2 Propofol attenuates lipopolysaccharide-induced hippocampal inflammation in septic mice The inflammatory response in the hippocampus was evaluated by Western blot analysis.
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Propofol inhibits neuroinflammation and metabolic reprogramming in microglia <i>in vitro</i> and <i>in vivo</i>.
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