Pre-dose levels of thrombospondin-1, fibronectin, periostin, and IL-6 showed a trend to elevation in the CKD cohort for all the factors examined except SPARC, which may be consistent with the disease state promoting overproduction of these proteins ( Supplementary Table S3 ).
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Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment.
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