The Way to Malignant Transformation: Can Epigenetic Alterations Be Used to Diagnose Early-Stage Head and Neck Cancer?

Biomedicines · 2023 · PMC10296077 · PMID 37371812

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a marked trendp < 0.001actually significant

They quantitated the LINE-1 methylation levels of each specimen by using pyrosequencing and showed that HNSCC specimens had a marked trend toward hypomethylation compared to control samples (46.8% vs. 54.0%, p < 0.001, Mann–Whitney).

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