“a marked trend”

They quantitated the LINE-1 methylation levels of each specimen by using pyrosequencing and showed that HNSCC specimens had a marked trend toward hypomethylation compared to control samples (46.8% vs. 54.0%, p < 0.001, Mann–Whitney).

There was a marked trend by a graphical representation that serum neuritin levels were increased in the order of the scores from 0 to 6 ( p < 0.001; Supplementary Figure S6B ).

Additionally, as the motion at the surgical level increased, there was a marked trend of decreasing LSDI scores, showing a strong negative correlation ( r = −0.802, p < 0.001) (Table 1 ).

On the other hand, in ch.7, none of the groups showed a marked trend ( r = 0.17, p = 0.056; Real group, r = −0.20, p = 0.14; Sham group).

In addition, there was a marked trend to higher LDL levels in the elevated IMR group, but the difference did not reach statistical significance ( p = 0.06). 3.3.

While there was no difference in humanization of the moving figures between all three groups, there was a marked trend that APS evaluated the figures as being less human compared to healthy participants (“humanization”; F(2) = 2.99, p = 0.064; post-hoc Bonferroni correction: pAPS = 0.064 (see all differences in Table 3 )). 3.3.

Lactis 420 at a dose of 10 10 CFU/day ( p = 0.020), and there was a marked trend of fat mass reduction by 10 9 CFU/day ( p = 0.066) [ 27 ].

Notably, the presence of allodynia showed a marked trend to significance towards association with a clinically meaningful response to fremanezumab (OR: 1.5; 95% CI: 0.6–3.3; p = 0.071).

Smad3-infected cells in the Ad-Smad3 and Ad-Smad3/Ad-FoxO3 groups showed significant increases in phosphorylated and total Smad3 in the cytoplasm ( Figures 6C, D ), a marked trend ( p = 0.08) for increased phosphorylated Smad3 in the nucleus ( Figure 6E ), and significantly increased total Smad3 in the nucleus ( Figure 6F ) compared to Ad-GFP cells.

Patients with worse GLS (≥−16%) demonstrated a marked trend toward a higher incidence of Fontan failure (67% vs. 20%, P = 0.09).

For the numbers of uncomplicated appendicitis there is a marked trend toward a lower number during the pandemic period compared with the pre-pandemic period in most studies.

Although not statistically significant (p = 0.09), this represented a marked trend towards a more favorable DFS among those with a higher H-score.

With the aid of solid-state SQUID magnetometry, we observed a marked trend of lesser antiferromagnetic coupling when expanding substitution to the heavier chalcogenide congeners which we attribute to the ∠Fe–E–Fe angle becoming more acute due to decreased hybridization in the heavier chalcogenides and poorer orbital overlap with Fe II d-orbitals.

Overall, there was a marked trend toward using various TEET options after 2017.

In U251 cells, the effect of PP2 on invasiveness was not significant; however, there was a marked trend towards a decrease in invasion ( Fig. 3B ).

Introduction Closed reduction (CR) is one of the most common procedures for treating late-detected developmental dislocation of the hips (DDH) ( 1 ), considering a marked trend toward spontaneous improvement of the hips after reduction ( 2 - 4 ).

A marked trend, increasing from low to high in terms of the parents’ level of education was observed (low: 31.6%; medium: 45.1%; high: 53.2%, Table S2 ).

This increase showed a marked trend in types such as ostomy, hearing, and physical disabilities.

A marked trend for improved recovery in both tests was detected in the rats in the WBV14 group.

However, the BoHV-4-M-NSP5 prime-boost vaccination showed a marked trend toward reduced lung pathology following PRRSV-1 challenge.

Between 2014 and 2017, rice of European origin showed a marked trend for certain pesticides that exceeded MRLs, such as in the case of isoprothiolane or carbendazim.

We observed a marked trend towards increased expression of total ezrin and phospho-ezrin in resistant melanoma cells under baseline conditions, which indicates that increased abundance of ezrin could be potentially linked with the vemurafenib-resistant phenotype in BRAFV600E-mutated melanoma cells. 2.6.

Under these circumstances, one can use hygroscopic metal salts (often hydrated salts) with a marked trend to capture water when mixed with organic anions, in such a way that the mixture, once sealed and subject to heat, may possess enough solvent as to completely mix the reagents and promote the crystallization aided by the autogenous pressure generated in the vessel.

As a result of this trend in patients, M1-macropage levels were significantly reduced at stage I compared to the control group and a marked trend was found for increased M1-levels at stage III compared to the control group ( Figure 4D ).

However, this was not observed when compared to the tumors treated with PBT+αPD1, despite a marked trend.