Increased plasma renin by vasodilators promotes the progression of abdominal aortic aneurysm.

It has been reported that hydralazine showed a trend toward aggravated AAA (1.59 ± 0.21 vs. 1.38 ± 0.03; hydralazine vs. vehicle) and atherosclerotic lesion areas (3.00 ± 0.40 vs. 1.74 ± 0.50 mm 2 , hydralazine vs. vehicle, and p = 0.06) in Ang II-infused mice, although the differences were not significant ( Cassis et al., 2009 ).

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