Serum Fibroblast Growth Factor-21 Discriminates Between Decompensated Alcohol-Associated Cirrhosis and Severe Alcohol-Associated Hepatitis.

Differences in FGF-21 concentrations were highly significant when compared among the 3 clinical phenotypes, with the highest levels again observed in AH (3,052 pg/mL) when compared to AC (1,235 pg/mL, P = 0.03) and no ALD (325.5 pg/mL, P = 0.02) (Figure 3 ).

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In our discovery cohort, recent alcohol exposure showed a trend toward lower FGF-21 concentrations, but we did not observe the same in our validation cohort.

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