Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells.

J Physiol Biochem · 2023 · PMC10300178 · PMID 36464762

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In addition, expression of MYD88, an adapter protein that mediates signal transduction from TLRs to NF-κB, showed a trend for increased expression in HUVEC exposed to extracellular histones (50 μg/ml) compared to non-treated cells (Suppl.

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