Barely Significant
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Combination therapy is not associated with improved rates of clinical or endoscopic remission in patients with inflammatory bowel disease treated with ustekinumab or vedolizumab: a retrospective study.

Ann Gastroenterol · 2023 · PMC10304522 · PMID 37396006

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quite significantno p-value reported
These include quite significant nausea and leukopenia, as well as an increased risk of serious infection or cancer, and lymphoma in particular.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.