Gut Microbiota-Mediated Pharmacokinetic Drug-Drug Interactions between Mycophenolic Acid and Trimethoprim-Sulfamethoxazole in Humans.

Pharmaceutics · 2023 · PMC10304707 · PMID 37376182

Europe PMC DOI

hedged sentence

0.0820

closest p · 1.6× alpha

0.0820

boldest claim

The sentences

did not reach statistical significancep = 0.082so close (0.05 < p ≤ 0.1)

MPA AUC 6–12 was also decreased by ∼30% (from 5.45 ± 3.22 to 3.79 ± 3.18 μg·h/mL) when MMF was co-administrated with TMP-SMX, but this finding did not reach statistical significance ( p = 0.082).

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