Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging.

Nat Immunol · 2023 · PMC10307630 · PMID 37217705

Europe PMC DOI

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0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

a strong trendP = 0.07so close (0.05 < p ≤ 0.1)

At 14 d after immunization, confocal microscopy confirmed the localization of CXCR5-deficient T FH cells to the dark zone and a strong trend ( P = 0.07) towards a diminished FDC network in Cxcr5 fl/fl ; Cd4 ERT2Cre mice compared with Cxcr5 +/+ ; Cd4 ERT2Cre controls (Extended Data Fig. 9 ).

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a nonsignificant trendno p-value reported

At 10 d after immunization, GCs had a nonsignificant trend to be smaller in recipients of CXCR4-deficient T cells (Fig. 4b,c ).

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