Personalized Dual Antiplatelet Therapy in Acute Coronary Syndromes: Striking a Balance Between Bleeding and Thrombosis.

Curr Cardiol Rep · 2023 · PMC10307718 · PMID 37261665

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

nearly significantp = 0.06so close (0.05 < p ≤ 0.1)

The latter study simply gave ticagrelor to patients with any LoF alleles and reported a nearly significant reduction in MACE (4.0% vs. 5.9%; HR, 0.66 [95% CI, 0.43–1.02]; p = 0.06), but the investigators noted that many subjects received newer-generation stents and had lower-than-anticipated event rates, which was not accounted for in their power calculation.

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