borderline non-significantp ≤ 0.08
Gene-based burden tests for the 10 new candidate SP predisposing genes combining the original and validation SP cohorts (meta-analysis) confirmed a significant association with SP for DKK4 , HECW1 , ITPR3 , and TLE4 (borderline non-significant for DKK1 and WNT9B; 0.05< p ≤ 0.08).