Saline nasal irrigation and gargling in COVID-19: a multidisciplinary review of effects on viral load, mucosal dynamics, and patient outcomes.

In line with these results, another randomized study of isotonic SI, initiated in hospitalized COVID-19 patients and leading to faster viral clearance Day 2 ( P < 0.02), suggests that rapid initiation of SI following a positive PCR test may help to lower subsequent need for oxygen administration, ICU admission, and mortality, although the differences did not reach statistical significance between the small patient groups ( n = 25 per group), and a potential bias may have incurred by the average older age of the control group ( 51 ). 3.3.3.2.

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