Additionally, while there was an overall trend towards improved survival across all stages, patients with metastatic disease at diagnosis (n=80) did not exhibit any difference in survival with metformin exposure, though this was relatively small cohort.
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Metformin is associated with improved clinical outcomes in patients with melanoma: a retrospective, multi-institutional study.
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The sentences
OS was numerically increased in nearly all stages exposed to metformin, though this did not reach statistical significance.