Methadone alters the peripheral inflammatory and central immune landscape following prenatal exposure in rats.

Adv Drug Alcohol Res · 2022 · PMC10312988 · PMID 37396628

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failed to reach statistical significanceno p-value reported

At baseline, the conditioned media of PBMCs isolated from rats with POE demonstrated elevated levels of TNF-α levels at baseline in rats with POE after 3 h in culture (saline: 1.051 ± 0.220 pg/ml, methadone: 3.009 ± 0.721 pg/ml, t -test, p = 0.0655) although this failed to reach statistical significance ( Figure 5A ).

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