<i>N</i>-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function.

NEU2 activity was significantly increased in the muscles of mdx mice and showed a nonsignificant trend for increase in the muscles of DMSXL mice ( Fig. 10M ).

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We found that concentrations of Sia-nucleotides, CMP-Neu5Ac, and CMP-Neu5Gc, involved in the synthesis of glycans, showed a trend toward an increase in both Npl del116 and Npl R63C mice compared to WT, while CMP-Neu5Gc levels in Npl R63C mice receiving ManNAc treatment were similar to those in the WT animals (fig.

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