Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.

Furthermore, all of the four EHOA loci are within tissue-specific regulatory regions for vascular/endothelial cells which we estimate is 2.8-fold higher than expected by chance alone (expected overlap=35%; 95% CI 0% to 75%), but, as we tested for enrichment within 16 different tissue-specific groups, 23 the enrichment was only nominally significant (p=0.011, online supplemental table S9 ).

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