Moreover, the correlation between the GSN level and brain atrophy were analysed, with the increase of global cerebral atrophy-frontal (GCA-F), PA and MTA scores, the plasma or CSF GSN showed a trend of initially increasing and then decreasing ( online supplemental figure S6A-F ), and the plasma GSN was significantly positively correlated with GCA-F and MTA by Spearman correlation analysis (GCA-F: r=0.256, p=0.020; MTA: r=0.250, p=0.038).
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