A study to evaluate association of nuclear grooving in benign thyroid lesions with RET/PTC1 and RET/PTC3 gene translocation.

Thyroid Res · 2023 · PMC10316543 · PMID 37394464

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indeterminate significanceno p-value reported

But, when nuclear grooves with oval shape, chromatin clearing, and nuclear overlapping, are seen in BTLs, they do cause a diagnostic dilemma, resulting in the diagnosis of “atypical cytology/indeterminate significance” on fine needle aspiration (FNA) samples [ 3 , 18 , 19 ].

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