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Uterine Artery Doppler in Screening for Preeclampsia and Fetal Growth Restriction.

Rev Bras Ginecol Obstet · 2018 · PMC10316938 · PMID 29913544

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a clear trendno p-value reported
22 23 There is a clear trend in the literature over the past 30 years toward attempting to predict pregnancy complications in the first trimester, a concept known as “inversion of the pyramid of prenatal care.” 23 Furthermore, apart from the fact that high-risk women can be monitored closely looking for signs of PE or fetal growth deviations, recent randomized trials and meta-analyses have shown that prevention is now possible through the use of low-dose aspirin, which when initiated before 16 weeks of gestation significantly reduces the risk of severe PE 24 25 that would otherwise require premature delivery.

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