Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence.

Biochem Soc Trans · 2023 · PMC10317171 · PMID 37294003

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showed a trendno p-value reported

In 105 subjects with AAT deficiency and COVID-19 infections in 10 European countries, poor outcome was more likely with PiZZ genotype than PiSZ; interestingly, only 14 subjects were receiving regular AAT augmentation and they showed a trend toward better outcome [ 61 ].

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