We observed a nominally significant association between higher fitness and lower risk of type 2 diabetes (OR = 0.97 per 1-unit higher genetically predicted fitness in ml O 2 ·min −1 ·kg −1 FFM, 95% CI: 0.94–1.00; p = 0.086); however, there was evidence of significant heterogeneity (Cochran’s Q p -value < 0.001), potentially indicating horizontal pleiotropy (Supplementary Table 6 ).
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Causal associations between cardiorespiratory fitness and type 2 diabetes.
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