Safety and efficacy of colchicine for the prevention of post-operative atrial fibrillation in patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials.

Although numerically higher, this difference in the risk of drug discontinuation in those receiving colchicine as compared to placebo did not reach statistical significance (RR: 1.33; 95% CI: 0.93–1.89; P = 0.11, I 2 = 0%) (COE: moderate certainty) ( Figure 3 ).

also in 111,027 other papers