Barely Significant
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Is Clozapine-induced Weight Gain Dose-dependent? Results From a Prospective Cohort Study.

Schizophr Bull · 2023 · PMC10318871 · PMID 36841954

Europe PMCDOI
1
hedged sentence
0.0470
closest p · 0.9× alpha
0.0470
boldest claim

The sentences

slightly significantP = .047actually significant
Since serum clozapine levels are influenced by smoking with polycyclic aromatic hydrocarbons (PAHs) present in tobacco smoke being a strong inducer of the clozapine metabolizer cytochrome P4501A, 8 a sensitivity analysis considering smokers ( N = 41, median dose 280 mg) and nonsmokers ( N = 74, median dose 130 mg) separately was applied, indicating a trend ( E = 0.81, P = .090) and a slightly significant ( E = 0.94, P = .047) effect of the dose on weight change, respectively, probably due to the low sample size.

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