Two Neuroanatomical Signatures in Schizophrenia: Expression Strengths Over the First 2 Years of Treatment and Their Relationships to Neurodevelopmental Compromise and Antipsychotic Treatment.

Expression strengths were similar between groups at baseline ( P = .4561), and while controls did not change significantly over time ( P = .4926) there was a highly significant increase in signature 2 strength in patients ( P < .0001), with significant differences between the groups at M12 ( P = .0047) and M24 ( P = .0086).

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For signature 2 there was a near-significant group*time interaction ( F = 3.1, P = .0510) and expression was similar in patients and controls at baseline ( P = .8222) but increased significantly from baseline to month 12 ( P = .0005) and month 24 ( P < .0001) in patients, but not in controls at month 12 ( P = .2471) and month 24 (0.4414).

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