Mutations in epigenetic regulator <i>KMT2C</i> detected by liquid biopsy are associated with worse survival in prostate cancer patients.

Although multiple factors were associated with shorter CRFS in univariate analyses, such as KMT2C mutations ( p = 0.019), de novo metastasis ( p = 0.020), AR pathway mutations ( p = 0.002), MAPK pathway mutations ( p = 0.001), PI3K pathway mutations ( p = 0.008), WNT pathway mutations ( p = 0.006), and total mutations ( p = 0.015), none of them remained the prognostic significance in multivariate analyses for CRFS (only KMT2C mutations and de novo metastasis displayed borderline significance; p = 0.059 and p = 0.067).

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Moreover, KMT2C mutations could effectively predict shorter PSA-PFS in 10 out of 23 subgroups and exhibited a strong trend in the remaining subgroups.

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