The influence of atrial high-rate episodes on stroke and cardiovascular death: an update.

Europace · 2023 · PMC10319778 · PMID 37345804

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a strong trendP = 0.06so close (0.05 < p ≤ 0.1)

warfarin in the prevention of stroke/systemic embolism (HR 0.81, 95%CI 0.73–0.91; P < 0.0001), and a strong trend toward fewer major bleedings (HR 0.86, 95% CI 0.73–1.00; P = 0.06).

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an observed trendno p-value reported

The reasons for early termination given by the DSMB are an observed trend towards futility for efficacy combined with safety concerns.

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