Consistent with this subtlety, we report a trend toward increased hyperactivity that did not reach statistical significance (p = 0.08) in an independent cohort of male GRN Tg mice (n = 18) ( Fig. 3 B).
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Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome.
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