Effects of proton therapy on regional [¹⁸F]FDG uptake in non-tumor brain regions of patients treated for head and neck cancer.

The correlation between the mean dose and SUVmean relative difference was significant in five assessed regions: R hippocampus (r (22) = 0.45, p = 0.03), L occipital lobe (r (23) = 0.52, p = 0.01), L parietal lobe (r (23) = 0.66, p = 0.001), frontal lobe (r (23) = 0.42, p = 0.05), and R occipital lobe (r (23) = 0.55, p = 0.01), and one assessed region, the cerebellum (r (23) = 0.37, p = 0.08), was close to being statistically significant ( Table 3a ).

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The correlation in the hippocampal regions probably did not reach statistical significance due to the limited sample size.

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