Except for OR2H2 and OR1L8 (female group) that, despite displaying a similar tendency, did not reach statistical significance, all other transcripts analyzed showed a clear and statistically significant downregulation in Braak I stage compared to non-demented controls, and in some cases also in stage II.
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Epigenetic silencing of OR and TAS2R genes expression in human orbitofrontal cortex at early stages of sporadic Alzheimer's disease.
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