Modeling Reduced Contractility and Stiffness Using iPSC-Derived Cardiomyocytes Generated From Female Becker Muscular Dystrophy Carrier.

JACC Basic Transl Sci · 2023 · PMC10322885 · PMID 37426526

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showed a trendno p-value reported

The active force of Δ45-48- DMD SOTRs was significantly decreased compared with that of WT- DMD SOTRs (0.507 ± 0.106 mN/mm 2 ; P = 0.012), and correction of the heterozygous PLOD3 stop-gain variant in Δ45-48- DMD -HDR SOTRs showed a trend but did not significantly improve the reduced force (0.757 ± 0.142 mN/mm 2 ; P = 0.086).

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