Combination therapy of DKK1 inhibition and NKG2D chimeric antigen receptor T cells for the treatment of gastric cancer.

Cancer Sci · 2023 · PMC10323088 · PMID 37151176

Europe PMC DOI

hedged sentences

0.0880

closest p · 1.8× alpha

0.1339

boldest claim

The sentences

did not reach statistical significancep = 0.088so close (0.05 < p ≤ 0.1)

Although the tumor volume did not reach statistical significance ( p = 0.088) after DKK1 treatment, the immune status was improved.

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a decreasing trendp = 0.1339not close (p > 0.1)

The FCM analysis indicated that DKK1 inhibition induced significantly higher infiltration of NK cells and lower infiltration of M2 macrophages in the tumors (Figure S1C,D ), and a decreasing trend of M2 macrophage infiltration in the spleens ( p = 0.1339; Figure S1G ).

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