Pyridylnidulin exerts anti-diabetic properties and improves non-alcoholic fatty liver disease in diet-induced obesity mice.

Interestingly, administration of PN, with any doses, and metformin provided a highly significant effect on the downregulation of CD36 mRNA expression ( p < 0.001) when compared to vehicle-treated DIO mice ( Figure 9D ).

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In our present study, PN-treated mice, especially the high dose, decreased the liver TG levels which was in accordance with downregulated gene transcription of SREBP-1c, Acaca, and FASN; however, the expression level did not reach statistical significance.

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