The distribution of T-cell populations in the spleen in the ICI-treated group demonstrated an overall trend of decreased CD8 + and increased CD4 + T cells over time, which reached statistical significance when compared with pretreatment.
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Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma.
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This trend was not found in the control group, where CD4 + T cells kept an overall stable percentage over time, and CD8 + T cells showed a trend of increase in proportion over time that did not reach any significance ( Fig. 1D ).